In a
meta-analysis of 19
randomized controlled trials in 728 older adults, resistance training reduced
C-reactive protein (CRP) and improved physical function.
The resistance training programs lasted 6 to 38 weeks, with 2 to 3 weekly sessions. The exercises included squats, leg presses, bench presses, and rows, performed at 30% to 85% of 1-repetition maximum (1RM) for 1 to 5 sets of 4 to 25 repetitions. The training methods used elastic bands, body weight, free weights, or machines.
Overall, resistance training reduced CRP levels with a moderate-to-large
effect size, and interleukin 6 and TNF-alpha remained unchanged. Resistance training also improved walking speed and
leg extension strength and reduced
body fat percentage.
Resistance training likely reduced CRP by lowering chronic low-grade
inflammation, possibly through improved muscle function,
[1] increased release of anti-inflammatory cytokines,
[2] and reductions in body fat, especially
visceral fat (a key driver of inflammation).
[3] However, interleukin 6 and TNF-alpha remained unchanged, likely because interleukin 6 has both proinflammatory and anti-inflammatory roles, whereas TNF-alpha is associated with short-term rather than long-term inflammation.
Nejatian Hoseinpour A, Bassami M, Ahmadizad S, Donath L, Setayesh S, Mirzaei M, Mohammad Rahimi GR
The influence of resistance training on inflammatory markers, body composition and functional capacity in healthy older adults: A systematic review and meta-analysis.Arch Gerontol Geriatr.(2025 Dec 25)
Source: www.examine.com